Effects of NSAIDS on activities of cartilage degrading enzymes in osteoarthritic knees

Effects of NSAIDS on activities of cartilage degrading enzymes in osteoarthritic knees - NSAIDS and OA cartilage degradation

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000721

Enrollment

Registered

2008-03-31

Start date

2007-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee

Interventions

Diclofenac (COX-1 and 2 supressor) Meloxicam (selective COX-2 supressor)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Osteoarthritic knees that require joint punctuation or joint injection on regular basis

Exclusion criteria

Exclusion criteria: 1) Gastric ulcer 2) Liver disfunction 3) Uncontrolled hypertension 4) Allergy against aspirin 5) Asthma indeuced by aspirin 6) Pregnancy 7) Other condtitions that are not suitable for the study judged by medical doctors

Design outcomes

Primary

Measure	Time frame
MMP-3,9,13 and TIMP-1,2 of joint fluid	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026