Randomized study of endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) using 3.4-mm thin bronchoscope vs. EBUS with guide sheath (GS)-guided TBB using 4.0-mm bronchoscope for diagnosis of peripheral pulmonary lesions

Randomized study of endobronchial ultrasound (EBUS)-guided transbronchial biopsy (TBB) using 3.4-mm thin bronchoscope vs. EBUS with guide sheath (GS)-guided TBB using 4.0-mm bronchoscope for diagnosis of peripheral pulmonary lesions - Randomized study of EBUS-guided TBB using thin bronchoscope vs. EBUS-GS-guided TBB for diagnosis of peripheral pulmonary lesions

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000696

Enrollment

260

Registered

2007-04-30

Start date

2007-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Benign or malignant pulmonary lesions

Interventions

EBUS-guided TBB using 3.4-mm thin bronchoscope EBUS-GS-guided TBB using 4.0-mm bronchoscope

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients with a peripheral pulmonary nodule or mass who need to undergo diagnostic bronchoscopy 2. 20 years old and above 3. Informed consent

Exclusion criteria

Exclusion criteria: 1. Case with serious concomitant medical illness 2. Central pulmonary lesions 3. Diffuse pulmonary lesions 4. Re-examination due to prior failure in this trial 5. Patients who need to undergo other bronchoscopic procedure (e.g. TBNA, BAL) 6. Bleeding tendency 7. Pregnant woman 8. Other clinical difficulties in this trial

Design outcomes

Primary

Measure	Time frame
Diagnostic yield; according to lesion size, location, benign or malignant	—

Secondary

Measure	Time frame
1.Frequency of adverse effects 2.Level of bronchus reached 3.Visibility on EBUS 4.Direct visibility of lesions with bronchoscope 5.Time of procedure	—

Countries

Japan

Contacts

Public ContactMasahide Oki

Nagoya Medical Center Department of Respiratory Medicine

052-951-1111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026