Kawasaki disease
Conditions
Interventions
The example of the Kawasaki disease that is not improved in gamma globulin treatment is made a contrast group, and the infliximab of 5 mg/kg is administered in the single time vein from July 1, 2005 t
Sponsors
Pediatrics Yokohama City Univesrity
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The improvement of the inflammation examination opinion such as clinical conditions, CRP and fever is not admitted by the IVGG treatment (4g/kg or less) among examples of the Kawasaki disease diagnosed by the Kawasaki's disease diagnosis standard of the Ministry of Health, Labour and Welfare. The case who can have received agreement from parents or the legal parental authority person by the document further in the example of the obstinacy syndrome of two years old or more of not finding abnormality in the cardiac function is targeted.
Exclusion criteria
Exclusion criteria: Case who shows clear state of infectious disease. Example of decline of cardiac function (EF 65% or less) syndrome. Case who showed allergic reaction against infliximab before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Development coronary lesion at 4 weeks after treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement of fever and inflammatory finding at 7 days and 4 weeks after treatment | — |
Countries
Japan
Outcome results
None listed