Open-label, single-center, randomized and parallel-group study to compare the effect of inhaled corticosteroids and leukotriene receptor antagonists in patients with cough variant asthma.

Open-label, single-center, randomized and parallel-group study to compare the effect of inhaled corticosteroids and leukotriene receptor antagonists in patients with cough variant asthma. - Controlled study to compare the effect of inhaled corticosteroids and leukotriene receptor antagonists in cough variant asthma

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000627

Enrollment

Registered

2007-03-01

Start date

2007-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cough variant asthma

Interventions

High dose budesonide 600mcg bid 3 months Low dose budesonide 200mcg bid 3 months Montelukast 10mg once a day 3 months

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 Chronic cough persisting for longer than 8 weeks without wheezing or dyspnea 2 No other concomitant respiratory disease within 8 weeks 3 Presence of airway hyperrespon- siveness 4 Symptomatic response of coughing to bronchodilators 5 Normal chest radiograph

Exclusion criteria

Exclusion criteria: 1 Current smoker 2 Past treatment with inhaled corticosteroids or leukotriene receptor antagonists 3 Receiving oral corticosteroids in the previous 2 months

Design outcomes

Primary

Measure	Time frame
Coughing symptom	—

Secondary

Measure	Time frame
1 Symptom 2 Capsaicin cough sensitivity 3 Methacholine airway responsiveness 4 Pulmonary function test 5 Inflammatory biomarker of induced sputum and peripheral blood 6 Safety 7 Progression to classical asthma	—

Countries

Japan

Contacts

Public ContactMasafumi Yamaguchi

Kyoto University Graduate School of Medicine Department of Respiratory Medicine

075-751-3830

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026