Patients diagnosed as having 75% or higher stenosis according to the AHA classification in at least one branch of the coronary artery with hypertension and hyperlipidemia.
Conditions
Interventions
Intensive Therapy Therapeutic Target BP <
120/80mmHg LDL-C <
80mg/dL
Conventional Therapy Therapeutic Target BP <
140/90mmHg LDL-C <
100mg/dL
Sponsors
J-CADII study committee
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) 20 years-old or older and less than 80 years-old 2) hyperlipidemia 3) hypertension 4) have 75% or more stenosis in at least one branch of the coronary arteries according to the AHA classification diagnosed by either CT or CAG 5) written informed consent to enter the study available
Exclusion criteria
Exclusion criteria: Patients are excluded from study inclusion if they have 1) allergy to test drugs 2) familial hypercholesterolemia 3) uncontrolled hyperlipidemia (LDL-C >= 180mg/dL) 4) uncontrolled hypertension (systolic blood pressure >= 180mmHg and/or diastolic blood pressure >= 110mmHg) 5) AMI and/or stroke within 3months before intervention 6) secondary hypertension 7) secondary hyperlipidemia 8) severe valvular disease including mitral stenosis or incompetence of the aortic valve 9) severe arrhythmia including ventricular fibrillation or ventricular tachyrhythmia 10) renal failure (serum creatinine >=2.5 mg/dL) 11) liver dysfunction (AST and/or ALT over three times the normal value) 12) pregnancy and/or possibility of pregnancy or if the attending doctor disqaulifies the patients to be included in the study for whatever reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Composite endpoint - all deaths, nonfatal MI/stroke/vascular/peripheral vessel events, unstable angina pectoris, all hospitalization and CABG Evaluated three years after intervention started. | — |
Countries
Japan
Contacts
Public ContactTsutomu Yamazaki
Tokyo University Graduate School of Medicine Department of Clinical Epidemiology and Systems
Outcome results
None listed