Chronic Heart Failure
Conditions
Interventions
Olmesartan 5-40mg daily, during the study period.
Control
Sponsors
Tohoku Heart Failure Association The SUPPORT Study Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who meet all of the following criteria. 1)Chronic heart failure patients with NYHA function class II, III, or IV. 2)Patients who have a history of hypertension or those who have antihypertensive medications. 3)Patients who are aged 20 years or older and less than 80 years at the entry. 4)Stable patients who have angiotensin converting enzyme inhibitor and/or beta-blocker. 5)Patients who do not have angiotensin II receptor blocker.
Exclusion criteria
Exclusion criteria: 1)Patients who have renal dysfunction (serum creatinine >=3.0mg/dL) or those who are receiving chronic hemodialysis. 2)History of drug hypersensitivity to olmesartan. 3)Patients who have severe liver dysfunction. 4)History of angioedema. 5)History of malignant tumor or life-threatening illness of poor prognosis. 6)Pregnant or possibly pregnant patients. 7)Cardiovascular surgery within 6months prior to the date of the entry. 8)Acute myocardial infarction within 6 months prior to the date of the entry. 9)Percutaneous coronary intervention or stent implantation within 6 months prior to the date of the entry. 10)Other patients deemed unsuitable as subjects of the study by the treating physician.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| A composite of all-cause death, nonfatal acute myocardial infarction, nonfatal stroke, and hospital admission due to congestive heart failure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes 1)all-cause death 2)cardiovascular death 3)death due to heart failure 4)sudden death 5)acute myocardial infarction 6)stroke 7)hospital admission from any cardiovascular reasons Other outcomes 1)fatal arrhythmia or appropriate ICD discharge 2)new-onset diabetes 3)development of renal failure 4)new-onset atrial fibrillation 5)a need to modify treatment procedures for heart failure 6)left ventricular ejection fraction 7)BNP | — |
Countries
Japan
Contacts
Public ContactNobuyuki Shiba
Tohoku University Graduate School of Medicine Department of Cardiovascular Medicine
Outcome results
None listed