Randomized controlled trial of esophagectomy versus chemoradiotherapy in patients with clinical stage I esophageal carcinoma JCOG0502

Conditions

Esophageal Carcinoma

Shun Yamamoto, Ken Kato, Hiroyuki Daiko, Yoshinori Ito, Takeshi Kajiwara et al. (19 authors)

Future Oncology2024-09-271 citations

10.1080/14796694.2024.2398985

Prognostic biomarker study in patients with clinical stage I esophageal squamous cell carcinoma: JCOG0502‐A1

Kotoe Oshima, Ken Kato, Yoshinori Ito, Hiroyuki Daiko, Isao Nozaki et al. (22 authors)

Cancer Science2021-12-289 citations

10.1111/cas.15251

Second primary malignancies in patients with clinical T1bN0 esophageal squamous cell carcinoma after definitive therapies: Supplementary analysis of the JCOG trial, JCOG0502.

Seiichiro Mitani, Ken Kato, Hiroyuki Daiko, Isao Nozaki, Takashi Kojima et al. (16 authors)

Journal of Clinical Oncology2020-05-20

10.1200/jco.2020.38.15_suppl.4565

Parallel-group controlled trial of esophagectomy versus chemoradiotherapy in patients with clinical stage I esophageal carcinoma (JCOG0502).

Ken Kato, Hiroyasu Igaki, Yoshinori Ito, Isao Nozaki, Hiroyuki Daiko et al. (19 authors)

Journal of Clinical Oncology2019-01-2924 citations

10.1200/jco.2019.37.4_suppl.7

Evaluation of preventive factors for postoperative pulmonary complications following esophagectomy for T1bN0M0 cancer using data from JCOG0502.

Isao Nozaki, Junki Mizusawa, Ken Kato, Hiroyasu Igaki, Yoshinori Ito et al. (20 authors)

Journal of Clinical Oncology2016-02-011 citations

10.1200/jco.2016.34.4_suppl.98

Determination factors of patients' decision between surgery and chemoradiotherapy for stage I esophageal carcinoma: From the results of JCOG0502—A comparative study of the two modalities.

Ken Kato, Hiroyasu Igaki, Yoshinori Ito, Isao Nozaki, Hiroyuki Daiko et al. (20 authors)

Journal of Clinical Oncology2015-01-20

10.1200/jco.2015.33.3_suppl.114

The prevalence of lymph node metastases in clinical T1N0 thoracic esophageal cancer from the results of JCOG0502.

Yasunori Akutsu, Ken Kato, Hiroyasu Igaki, Yoshinori Ito, Isao Nozaki et al. (20 authors)

Journal of Clinical Oncology2015-01-20

10.1200/jco.2015.33.3_suppl.10

Safety profile of thoracoscopic esophagectomy for esophageal cancer compared with traditional thoracotomy from the results of JCOG0502: A randomized trial of esophagectomy versus chemoradiotherapy.

Isao Nozaki, Ken Kato, Hiroyasu Igaki, Yoshinori Ito, Hiroyuki Daiko et al. (20 authors)

Journal of Clinical Oncology2014-01-201 citations

10.1200/jco.2014.32.3_suppl.82

Interventions

A:Esophagectomy with D2 (or more) lymph node desection B:Chemoradiation 5FU 700mg/m2/day civ Day1-4, 29-32 CDDP 70mg/m2/day div Day1, 29 radiation 60Gy/30fr/6w

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: (1)Histologically proven esophageal cancer (squamous cell carcinoma, adenosquamous cell carcinoma, besaloid carcinoma) (2)all lesions are localized in thoracic esophagus. (3)The depth of main lesion is endoscopically diagnosed submucosa. (4)No lymphnode metastasis and no distant metastasis. (5)No prior chemotherapy and/or radiotherapy. Only curative endoscopic mucosal resection is allowed. (6)ages 20 years-75years (7)PS(ECOG) 0-1 (8)Normal organic function. (9)oral or written informed consent obtained before randomization

Exclusion criteria

Exclusion criteria: (1)synchronous or metachronous (within 5 years) malignancy (2)Pregnant or lactating (3)psychiatric medication (3)Systemic administration of steroids (4)HBsAg positive (5)Use of insulin injection therapy or uncontrolled diabetes mellitus (6)History of acute myocardial infarction (within 3 months) or unstable angina (7)Severe complecations (COPD, pulmonary fibrillation, heart failure etc.) (8)active bacterial infection

Design outcomes

Primary

Measure	Time frame
Overall Survival	—

Secondary

Measure	Time frame
Complete Response Rate, Adverse Events	—

Countries

Japan

Contacts

Public ContactKen Kato

JCOG0502 Coordinating Office Gastrointestinal Oncology, National Cancer Center Hospital

JCOG_sir@ml.jcog.jp03-3542-2511

Outcome results

None listed