A Randomized Investigation of Short-term Prognosis and Costs and Long-term Prognosis of Medical vs. Coronary Intervention for Low-risk Stable Effort Angina

A Randomized Investigation of Short-term Prognosis and Costs and Long-term Prognosis of Medical vs. Coronary Intervention for Low-risk Stable Effort Angina - Japanese Stable Angina Pectoris Study (JSAP Study)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-UMIN000000530

Enrollment

400

Registered

2006-11-27

Start date

2002-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

low-risk stable effort angina

Interventions

medical therapy as the initial treatment coronary intervention as the initial treatment

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: low-risk stable effort angina indicating 1-vessel or 2-vessel disease without stenotic lesions in LMT or the ostial leasion in LAD (within 5 mm from the bifurcation) in whom CAG shows significant stenosis in the culprit lesion, and PCI/CABG is indicated

Exclusion criteria

Exclusion criteria: 1) Lesions in LMT or at the ostial site of LAD (within 5 mm from bifurcation) 2) 3-vessel disease 3) 2-vessel chronic total obstruction 4) 1-vessel chronic complete obstruction for which the possibility of PCI success is low (long-term chronic complete obstruction, long complete obstruction lesions) 5) Acute myocardial infarction 6) Ejection fraction of left ventricle less than 50% 7) Lesions not indicated for PCI/CABG (thin lateral branches, peripheral branches) 8) Complications such as bleeding tendency, DIC, and severe pneumonia 9) Impaired renal function (Cr > 1.5 mg/dl) 10) Patients with severe ASO and aneurysms not indicated for PCI/CABG 11) Patients with asymptomatic myocardial ischemia not complicated by effort angina pectoris 12) Patients with unstable angina pectoris who newly developed symptoms or showed aggravation within 6 weeks 13) CABG patients with graft stenosis as a responsible lesion

Design outcomes

Primary

Measure	Time frame
death (total death, cardiac death, sudden death), acute coronary syndrome (Q-wave infarction, non-Q wave infarction, unstable angina pectoris), and cerebrovascular diseases such as cerebral infarction and cerebral hemorrhage	—

Secondary

Measure	Time frame
angina pectoris classification and evaluation of survival	—

Countries

Japan

Contacts

Public ContactKazuhiko Nishigaki, MD

Gifu University Graduate School of Medicine Second Department of Internal Medicine

nissy@gifu-u.ac.jp058-230-6523

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026