protection of post ERCP pancreatitis
Conditions
Interventions
Observations of patient is conducted between 24 hours before ERCP and the start of manipulation . Risperidone is administered between 2 and 0.5 hours before ERCP in group of Risperidone.Urinastatin at
Sponsors
Faculty of Medicine, University of Tokyo
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients who are planned ERCP.Patients who fully understand and are willing to give a written informed consent about participation.circulatory failure.
Exclusion criteria
Exclusion criteria: Patients with a history of Endoscopic sphincterotomy. Patients have acute pancreatitis or acute exacerbation of chronic pancreatitis need the fasting therapy. Patients have disseminated intravascular coagulation,sepsis,acute. Patients have severe disturbance of consciousness than Japan Coma Scale1-1. Patients have severeheart disease,hepatic insufficiency,compromised renal function,endocrine disease,and gastrointestinal tract disturbance. Pregnant and breast-feeding women or women suspected of being pregnant,women are not willing to avoid pregnancy during the duration of study . Patients on Risperidone. Patients with a history of severe hypersensitivity to the Risperidone and Urinastatin. Patients have mental illness or depression who need continued medication or can not comply with the protocol. Patients with Parkinson's disease or parkinsonism. Patients receiving banned drug within 2 weeks before pre-observations. Patients with a history of enrolled in this clinical trial. Somebody who are found unfit to be patients by investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of post ERCP pancreatitis patient.The standard basis for diagnostic criterion of post ERCP pancreatitis are as follows. Over three times more than exceed the serum amylase level limit after 18hours post ERCP.Epigastric pain of more than 24 hours. | — |
Countries
Japan
Contacts
Public ContactHiroyuki Isayama
Faculty of Medicine, University of Tokyo Department of Gastroenterology
Outcome results
None listed