Prospective comparative study of neurocognitive function after total arch replacement: intermittent pressure augmented or conventional retrograde cerebral perfusion

Prospective comparative study of neurocognitive function after total arch replacement: intermittent pressure augmented or conventional retrograde cerebral perfusion - Comparative study of neurocognitive function: intermittent pressure augmented or conventional retrograde cerebral perfusion

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000435

Enrollment

Registered

2006-06-23

Start date

2006-06-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients undergoing total arch replacement

Interventions

Intermittent pressure augmented retrograde cerebral perfusion Conventional retrograde cerebral perfusion

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients undergoing total arch replacement via midline incision 2. Patients undergoing the first-time cardiovascular operation 3. Patients given written informed consent

Exclusion criteria

Exclusion criteria: 1. Patients having a history of cerebrovascular disease 2. Patients requiring emergency operation 3. Patients undergoing total arch replacement via left thoracotomy 4. Patients requiring concomitant valve or coronary-bypass operation 5. Severe liver disease 6. Severe renal disease 7. Patients whom physician judges inappropriate to the study

Design outcomes

Primary

Measure	Time frame
Neurocognitive function assessed by the revised Wechsler Adult Intelligence Scale	—

Countries

Japan

Contacts

Public ContactTakayuki Ono

University of Tokyo Cardiothoracic Surgery

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026