Sodium Bicarbonate Infusion at Low Concentration to Reduce Kidney Insufficiency by Angiographic Non-iodinated Contrast Media

Sodium Bicarbonate Infusion at Low Concentration to Reduce Kidney Insufficiency by Angiographic Non-iodinated Contrast Media - BLOCKADE

Status

Unknown

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000419

Enrollment

500

Registered

2006-05-16

Start date

2006-05-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Contrast-Induced Nephropathy

Interventions

administer 154 mEq/L of sodium bicarbonate intravenously, as a bolus of 3 mL/kg/hr for 1 hour before coronary angiography, followed by an infusion of 1 mL/kg/hr for 6 hours after coronary angiography

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: individuals with moderate renal insufficiency (serum creatinine concentration exceeding 1.2 mg/dL within 3 months) who are scheduled for coronary angiography

Exclusion criteria

Exclusion criteria: individuals with preexisting dialysis, anticipated dialysis after coronary angiography, acute coronary syndrome, emergency catheterization, overt congestive heart failure, administration of contrast within the previous 3 days and anticipated readministration of contrast following 3 days

Design outcomes

Primary

Measure	Time frame
the incidence of contrast-induced nephropathy within 2 days of coronary angiography	—

Secondary

Measure	Time frame
the incidence of adverse events, the change of glomerular filtration rate in one year and the occurrence of clinical events within one year of coronary angiography	—

Countries

Japan

Contacts

Public ContactTamaki Suyama

Kyoto University Hospital Department of Cardiovascular Medicine

suyama@kuhp.kyoto-u.ac.jp075-751-4255

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026