A randomazied controlled study to evaluate efficacy of low-energy extracorporeal cardiac shock wave therapy in patients with severe coronary artery disease

A randomazied controlled study to evaluate efficacy of low-energy extracorporeal cardiac shock wave therapy in patients with severe coronary artery disease - Effect of low-energy extracorporeal cardiac shock wave therapy in patients with severe coronary artery disease

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000389

Enrollment

Registered

2006-04-01

Start date

2006-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic heart disease

Interventions

Extracorporeal cardiac shock wave therapy (3 times a week/series, 200 shots/spot at 0.09 mJ/mm2 for 20-120 spots each time) Placebo treatment (3 times a week/series)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with severe coronary artery disease suffered from stable effort angina with evidence of myocardial ischemia even after adequate medications and with no indication of percutaneous coronary intervention or coronary artery bypass grafting because of diffuse distal coronary artery narrowing.

Exclusion criteria

Exclusion criteria: 1. Q-wave or non-Q-wave myocardial infarction within 3 months. 2. Cardiac transplantation. 3. Left ventricular thrombus. 4. Poorly controlled diabetic retinopathy. 5. Malignant tumor including operation for the tumor within 5 years. 6. PCI and/or CABG within 3 months.

Design outcomes

Primary

Measure	Time frame
Regional myocardial ischemia. Evaluated at 3 month after the therapy.	—

Secondary

Measure	Time frame
Symptoms (CCS class scores, Frequency in use of nitroglycerin per week), Exercise tolerance. Evaluated at 3 month after the therapy.	—

Countries

Japan

Contacts

Public ContactKenta Ito

Tohoku University Graduate School of Medicine Department of Cardiovascular Medicine

cswt@cardio.med.tohoku.ac.jp022-717-7153

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026