An open label randomized controlled trial on the preemptive risedronate intervention for glucocorticoid-induced osteoporosis in chronic kidney disease patients

An open label randomized controlled trial on the preemptive risedronate intervention for glucocorticoid-induced osteoporosis in chronic kidney disease patients - The Preemptive Risedronate Intervention for those Undergoing Steroid therapy with Chronic Kidney Diseases (PRIUS-CKD Study )

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000387

Enrollment

100

Registered

2006-04-01

Start date

2003-08-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glucocorticoid-induced osteoporosis in CKD patients

Interventions

Active vitamin D alone (1 year) Active vitamin D + risedronate (1 year) Risedronate alone (1 year)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Outpatients with chronic kidney diseases in the nephrology unit of Osaka University Hospital who have been receiving glucocorticoid (2.5mg/day of prednisolone equivalent or greater) for more than 6 months. Creatinine clearance equal to or over 30 mL/min is required for the inclusion.

Exclusion criteria

Exclusion criteria: Patients receiving specific treatments that affect bone and mineral metabolism such as SERM, HRT, calcitonin, recombinant human PTH, and other bisphosphonate, except for active vitamin D. Patients in or expecting pregnancy

Design outcomes

Primary

Measure	Time frame
Change in bone mineral density at one year interval	—

Secondary

Measure	Time frame
Changes in bone turnover markers, PTH, and indices of renal function. Safety. Compliance	—

Countries

Japan

Contacts

Public ContactTakahito Ito

Osaka University School of Medicine Department of Nephrology

taka@medone.med.osaka-u.ac.jp06-6879-3632

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026