IgA nephropathy
Conditions
Interventions
combined therapy by tonsillectomy and steroid pulse therapy
steroid pulse therapy alone
Sponsors
Research Group for Tonsillectomy and Steroid Pulse therapy in IgA naphropathy
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients with biopsy-prove IgA nephropathy 2)Relatively good prognosis group, relatively poor prognosis group and poor prognosis group 3)Urinary protein excretion is 1.0g/day or more and serum creatinine is less than 1.5mg/dl 4)Patients having chronic tonsillitis or recurrent tonsillitis 5)Systolic blood pressure is less than 140 mmHg and diastolic blood pressure is less than 90 mmHg with or without antihypertensive drugs
Exclusion criteria
Exclusion criteria: 1)Patients with nephrotic syndorome 2)Patients whose serum creatinine is 1.6mg/dl or more 3)Patients who have been treated with steroid 4)Pregnant women or women of child bearing potential and nursing women. 5)Patients who can not be given anesthetic because of cardiac failure, respiratory failure or uncontrollable severe hypertension 6)Patients in whom tonsillectomy should not be done by the decision of otorhinolaryngologists because of the difficulty of tonsillectomy or no indication 7)Patients with hypersensitivity to the drugs used in the study 8)Patients who are judged to be inappropriate for the study by the investigator or subinvestigator
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1)change in creatinine clearance from baseline, slope of 1/serum creatinine vs. time 2)incidence of events (doubling of serum creatinine or 50% decrease in creatinine clearance from baseline and dialysis) 3)percentage of adverse effects | — |
Primary
| Measure | Time frame |
|---|---|
| 1)change in 24-hour urinary protein excretion and the degree of microscopic hematuria from baseline, 2)percentage of patients with clinical remission, i.e., without proteinuria and hematuria | — |
Countries
Japan
Contacts
Public ContactYasunori Utsunomiya
The Jikei University School of Medicine Division of Kidney and Hypertension
Outcome results
None listed