Bronchial asthma
Conditions
Interventions
Combination therapy of inhaled corticosteroid and oral theophylline
Sponsors
Graduate school of biomedical sciences, Hiroshima university, department of molecular and internal medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Bronchilal asthma patients, aged 20 to 70, smoker and non smoker, inhaled corticosteroid use=>1 month, theophylline free=> 1 month. Smoker means a current smoker who continues to smoke after steady instructions of smoking cessation. Non-smoker means a never smoker or an ex-smoker who stopped smoking more than 3 years ago and smoking index is less than 10 pack-years. Patients who uses inhaled corticosteroid for more than 1 month. Patients who have signed the agreement for participation in this study
Exclusion criteria
Exclusion criteria: Patients who used theophylline and oral or intravenous corticosteroid within 1 month, Patients who had acute exacerbation of ashtma within 1 month. Patients who cannot perform spirogram, Patients with respiratory infection, glaucoma , or pepcic ulcer In addition to the above exclusion criteria, patients judged to be inadequate to participate in this study by their physician
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morning peakflow | — |
Secondary
| Measure | Time frame |
|---|---|
| Evening peakflow Spirogram Blood concentration of theophylline Induced sputum | — |
Countries
Japan
Contacts
Public ContactYoshinori Haruta
Graduate school of biomedical sciences, Hiroshima university Department of molecular and internal medicine
Outcome results
None listed