Hypertensive patients undergoing trice-weekly hemodialysis
Conditions
Interventions
Enrolled patients were randomly assigned with a two-by-two factorial design to either 1 of 2 levels of pre-dialytic mean arterial pressure (BP) goals, 105 to 110 mmHg (usual BP group, around 140/90 mm
consultation, repeated confirmation of patients'
dry weight, a longer dialysis session including ultrafiltration, add-on of open-label antihypertensive agents (alfa-adrenergic antagonists, direct-acting vasodilator, beta-adrenergic antagonists, cent
Sponsors
Div. Nephrology, GenGen-Do Kimitsu Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Hypertensive patients, 23 to 70 years of age, all Japanese, who were undergoing outpatient hemodialysis thrice weekly for three or more months were enrolled between January 1996 and December 1999. Hypertension was defined as averaged office pre-dialysis BP at sitting position of 150/90 mm Hg or more with or without antihypertensive medications for a minimum of three month before randomization.
Exclusion criteria
Exclusion criteria: patients with preserved residual renal function (urine volume of more than 500 mL per day), pre-dialysis BP of less than 140/60 mm Hg, unstable homodynamic during hemodialysis therapy, a history of drug-allergy, accelerated or malignant hypertension within six months, secondary hypertension, severe systemic diseases, including cardio-,cerebro- and peripheral vascular, pulmonary, and gastrointestinal and hepatic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| death from all causes | — |
Secondary
| Measure | Time frame |
|---|---|
| CVD (atherosclerotic heart disease including acute myocardial infarction, cardiomyopathy, cerebrovascular accident, cardiac arrhythmia and cardiac arrest of unknown causes) and first hospitalization for fetal and non fetal CVD events. | — |
Countries
Japan
Contacts
Public ContactNAOYUKI NAKAO
Rokko Island Hospital Div. Nephrology
Outcome results
None listed