Diabetic nephropathy
Conditions
Interventions
None listed
Sponsors
RIKEN
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Type 2 diabetic patients were divided into two groups according to the stage of diabetic nephropathy and diabetic retinopathy. 1) Nephropathy cases:Patients with diabetic retinopathy as well as overt nephropathy, urinary albumin excretion rates (AER) greater than 200 micro-g/min or urinary albumin/creatinine rations (Alb/Cr) greater than 300 mg/gCr, or patients under chronic renal-replacement therapy. 2) Control:Patients with diabetic retinopathy but without any sign of renal dysfunction, AER less than 20 micro-g/min or Alb/Cr less than 30 mg/gCr.
Exclusion criteria
Exclusion criteria: Patients with other chronic renal diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diabetic patients with diabetic retinopathy were divided into two groups: 1) nephropathy cases (DN):-patients with overt nephropathy, 2) controls (C):-patients showing no evidence of renal dysfunction (based on the urinary albumin levels). Our first screening involved genotyping 94 DNs and 94 Cs for 10,000 SNP loci, and we further analyzed the SNP loci showing significant differences in allelic frequencies between DN and C using a larger number of patients. | — |
Countries
Japan
Contacts
Public ContactShiro Maeda
SNP Research Center, RIKEN Laboratory for Diabetic Nephropathy
Outcome results
None listed