esophageal squamous cell carcinoma
Conditions
Interventions
Photodynamic therapy
Sponsors
National Cancer Center Hospital East
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients with esophageal squamous cell carcinoma who were treated with defenitive chemoradiotherapy 2) Patients` refusal of salvage surgery 3) assessed cancerous lesion limited within the submucosal layer by EUS 4) histolical confirmation of squamous cell carcinoma from the lesion 5) Performance status(ECOG): 0, 1, 2 6) Written informed consent 7) adequate organ function, defined as; WBC; 3000-12000/mm3, platelet count; >100000/mm3, serum creatinine level <1.5mg/dl, serum bilirubin level<2.0mg/dl, serum transaminase<100IU/l
Exclusion criteria
Exclusion criteria: 1) No other active malignancy 2) No other severe medical conditions 3) Patients who are suffered systemic infection 4) Patients who cannot keep shading 5) Lesions were judged within mucosal laiyer, and can be treated with EMR 6) Lesions were assessed as T4 before CRT. 7) clinically defined distant or lymph node metastasis by computed tomography and endoscopic ultrasound (EUS) before PDT 8) Patients with porphyria 9) Lesions were not completely evaluated because of stenosis after CRT
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate of primary site | — |
Secondary
| Measure | Time frame |
|---|---|
| Occurence rate of adverse event Progression free survival Overall survival | — |
Countries
Japan
Contacts
Public ContactTomonori Yano
National Cancer Center Hospital East Division of digestive endoscopy and GI oncology
Outcome results
None listed