Mitral Valve repair/replacement
Conditions
Interventions
None listed
Sponsors
National Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Patients who are expected to undergo mechanical mitral valve replacement or mitral valuvuloplasty. 2) Patients >= 40 and < 75 years of age. 3) Patients willing and able to give informed consent
Exclusion criteria
Exclusion criteria: 1) history of symptomatic stroke 2) present active infectious endocarditis 3) prior or planned operation of aortic valve or tricuspid valve 4) history of myocardial infarction within the past 6 months 5) PTCA or CABG is planned, or done within past 6 months 6) History of or suspected malignant tumor 7) Females of known or suspected pregnancy 8) Patients with recurrent deep venous thrombosis, or with genetic tendency of hypercoagulability 9) Abnormal results of labolatory data (chemical,CBC) within past 1 month 10) Patients with any contraindication of brain MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) The changes of the scores of the higher cognitive function test battery 2) Post-operative incidence rate of asymptomatic cerebral infarction | — |
Countries
Japan
Outcome results
None listed