Randomized double-blind placebo-controlled study of the efficacy of food containing bovine lactoferrin for suppression of colorectal polyps

Randomized double-blind placebo-controlled study of the efficacy of food containing bovine lactoferrin for suppression of colorectal polyps - Placebo-controlled study of lactoferrin for colorectal polyps

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000182

Enrollment

105

Registered

2006-07-03

Start date

2002-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

colorectal polyps(adenomas)

Interventions

Intake of six tablets containing lactoferrin(500 mg) daily for one year Intake of six tablets containing lactoferrin(250 mg) daily for one year Intake of six placbo tablets daily for one year

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have colorectal adenomas with a diameter of 5 mm or less. Patients without total large bowel resection. Patients without cancer. Patients without allergy to either milk or dairy products. Patients without any active infections, such as hepatitis B, hepatitis C, and HIV. Patients who are not using NSAIDs regularly. Patients with a white blood cell count of 3,000/ul or more, and a platelet count of 100,000/ul or more.

Exclusion criteria

Exclusion criteria: Patients with a history of large bowel resection within three years before the start of the study. Patients with inflammatory bowel disease. Patients with familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer. Patients using farnesyltransferase inhibitors regularly.

Design outcomes

Primary

Measure	Time frame
Change of colorectal adenoma diameter on colonoscopy.	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026