Symptomatic occlusion or stenosis of internal carotid artery or middle cerebral artery
Conditions
Interventions
None listed
Sponsors
JET-2 Study Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Recently symptomatic cerebral ischemic attacks due to occlusive lesions in the carotid territory demonstrated by cerebral angiography or magnetic resonance angiography. Transient ischemic attack (TIA) or ischemic minor stroke in the hemispheric carotid territory on the side of the occlusive lesions. Most recent qualifying TIA or stroke occurring within 6 months prior to enrollment. Age less than or equal to 73 years old. Modified Rankin Scale: 0-2. Competent to give informed consent Computed tomography (CT) or MRI demonstrating no diffuse cerebral infarction or no enhancement after infusion of contrast agent. Angiography showing occlusion or severe stenosis of internal carotid artery or middle cerebral artery trunk (M1). Quantitative measurement of cerebral blood flow (CBF) by positron emission tomography (PET), single photon emission computed tomography (SPECT), xenon-CT performed at least 3 weeks after the most recent attack. Cerebrovascular reserve capacity (CVR) is defined as [(CBF after infusion of acetazolamide-rest CBF)/ rest CBF] X 100% Definition of Groups Mild cerebral ischemia is classified into 4 groups based on the rest CBF and CVR. A: 80%<Rest CBF<90% AND CVR<10% B: Rest CBF<80% AND 10%<CVR<20% C:80%<RestCBF<90% AND10%<CVR<20% D: Rest CBF<90% AND 20%<CVR<30%
Exclusion criteria
Exclusion criteria: 1. Severe neurological conditions (Rankin disability scale 3,4,5) 2. Non-atherosclerotic vascular disease of caotid artery territory 3. Malignancy, renal insufficiency, heart failure, hepatic failure, renal failure 4. Acute myocardial infarction within previous 6months 5. Fasting glucose level > 300mg/dl, 6. Diastolic blood pressure >110mmHg 7. Artery to artery embolism 8. Cardioembolism 9. Acute, progressing or unstable neurological deficit
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Completed stroke (Rankin disability scale3,4,5) 2.Vascular death 3.Death and severe disability of other causes 4.Bypass surgery requested by neurologists due to impending stroke on the ipsilateral side | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Ipsilateral stroke (Rankin disability scale3,4,5) 2.Death due to ipsilateral stroke | — |
Countries
Japan
Contacts
Public ContactKoji Iihara
National Cardiovascular Center Neurosurgery
Outcome results
None listed