Symptomatic internal carotid artery or middle cerebral artery occlusion or stenosis
Conditions
Interventions
Medically-treated group (antiplatelet drug: ticlopidine and/or aspirin)
Surgically-treated group (arterial bypass surgery with medication of antiplatelet drug)
Sponsors
JET Study Group
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) History: TIA(s) or minor completed stroke(s) in the carotid distribution, within 3 months prior entry. 2) Clinical findings: patients with useful residual function (Rankin disability scale 1 or 2). 3) CT or MRI: normal or border zone infarction. 4) Angiography: uni- or bilateral, ICA or MCA, occlusion or severe stenosis due to arteriosclerosis. 5) Baseline CBF less than 80% of normal control and CVRC less than 10%.
Exclusion criteria
Exclusion criteria: 1) Rankin disability scale 3,4,5. 2) non-atherosclerotic lesion. 3) patients with malignant neoplasm, renal failure, cardiac failure, hepatic failure or lung failure. 4) myocardial infarction within six months. 5) diabetus mallitus with FBS more than 300 mg/dl or during treatment using insulin. 6) diastolic arterial pressure more than 110 mmHg.7) artery to artery embolism, 8) cardioembolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Completed stroke (Rankin disability scale 3, 4 or 5). 2) Major cardiovascular morbidity and death. 3) Other cause of death and severe disability. 4) Patients who are necessary to undergo additional procedures or a second EC/IC bypass on the same side. | — |
Secondary
| Measure | Time frame |
|---|---|
| Completed stroke (Rankin disability scale 3, 4 or 5) due to the occlusive artery enrolled into the study. | — |
Countries
Japan
Contacts
Public ContactKuniaki Ogasawara
Iwate Medical University Department of Neurosurgery
Outcome results
None listed