Phase I study of S-1 with concurrent thoracic radiation therapy for elderly inoperable locally advanced non-small-cell lung cancer

Phase I study of S-1 with concurrent thoracic radiation therapy for elderly inoperable locally advanced non-small-cell lung cancer - S-1 with radiotherapy for elderly locally advanced non-small-cell lung cancer

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000132

Enrollment

Registered

2005-09-12

Start date

2005-09-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Elderly inoperable locally advanced non-small-cell lung cancer

Interventions

S-1 with concurrent thoracic radiation therapy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Histologically and/or cytologically proven NSCLC No prior surgery, chemotherapy, or radiotherapy Age > 75 Unresectable stage IIIA or IIIB ECOG performance status 0 or 1 Measurable disease Ample bone marrow, lung, hepatic, and renal function Signed informed consent

Exclusion criteria

Exclusion criteria: Involvement of contralateral hilar node, dissemination to pleura/pericardium, or malignant pleural/pericardial effusion Active concomitant malignancy History of chemotherapy or thoracic radiotherapy for previous malignancy Interstitial pneumonia Unstable angina, recent myocardial infarction Uncontrolled diabetes Severe active infection Other severe complications Judging of inappropriate condition for this study by physician.

Design outcomes

Primary

Measure	Time frame
maximum-tolerated doses and the recommended dose for phase II	—

Secondary

Measure	Time frame
response rate	—

Countries

Japan

Contacts

Public ContactNagio Takigawa

Okayama Lung Cancer Study Group Coordinating Office Department of Respiratory Medicine, Okayama University Hospital

ntakigaw@md.okayama-u.ac.jp086-235-7227

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026