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A randomised controlled trial to evaluate the effectiveness of perioperative immunonutrition and synbiotics in living-donor liver transplant recipients on reduction of postoperative infectious complication.

A randomised controlled trial to evaluate the effectiveness of perioperative immunonutrition and synbiotics in living-donor liver transplant recipients on reduction of postoperative infectious complication. - Effectiveness of immunonutrition and synbiotics in liver transplant recipients.

Status
Unknown
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-C000000125
Enrollment
105
Registered
2005-09-07
Start date
2005-09-01
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients scheduled for living-donor liver transplantation.

Interventions

Enteral nutrition (Elental, Ajinomoto Pharma, Japan) start via an intraoperatively placed ileostomy as soon as tolerated, within 5 days after surgery at the latest. Feeding begin at 10ml/hr, advance t

Sponsors

Department of Infection Control and Prevention, Kyoto University Hospital
Lead Sponsor
Department of Transplantation Immunology, Kyoto University Hospital
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients scheduled for living-donor liver transplantation with written informed consent.

Exclusion criteria

Exclusion criteria: transplantation for fulminant hepatitis, re-transplantation, ABO incompatibility, weight loss >=10% (with respect to usual body weight) in the past 6 months, respiratory dysfunction (arterial PaO2 3mg/dl, hemodialysis), cardiac dysfunction (New York Heart Class >=3), pregnancy, ongoing infection, neoadjuvant radiochemotherapy, allergy to components of immunonutrition (protein derived from milk, soybean, peanuts, gelatin)

Design outcomes

Primary

MeasureTime frame
The rate of postoperative infectious complication.—

Secondary

MeasureTime frame
Amount of antibiotic therapy, Duration of hospital stay, Acquisition of resistant bacteria, Postoperative mortality, The rate of postoperative non- infectious complication (wound dehiscence, rejection, bleeding, re-operation, anastomotic leak).—

Countries

Japan

Contacts

Public ContactNaoko Fujihara

Kyoto University Hospital Department of Infection Control and Prevention

075-751-4237

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026