Patients with impaired fasting glucose or type-2 diabetes mellitus, who had coronary artery diseases
Conditions
Interventions
Patients treated with voglibose (n=100)
Patients treated with nateglinide (n=100)
patients treated without medication, with diet and exercise (n=100)
Sponsors
National Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) patients who had organic stenosis in coronary angiography 2) patients who were diagnosed as impaired glucose tolerance or diabetes mellitus by a 75g-OGTT
Exclusion criteria
Exclusion criteria: 1) patinets with acute myocardial infarction within 48 hrs 2) patients who previously underwent coronary artery bypass surgery 3) patients who were being treated by anti-diabetic medication 4) patients who had allergic reaction to voglibose or nateglinide 5) patients with real insufficiency (serun creatinine more than 2.0mg/dl) 6) patients who were seriously ill
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lesion length, vessel diameter, percentage diameter stenosis | — |
Secondary
| Measure | Time frame |
|---|---|
| MACE (all-cause death, non-fatal myocardial infarction, repeat revascularization, the occurrence of anginal chest pain), diabetic complication, the change of % diameter stenosis after PCI, the change of minimum lesional diameter after PCI, the occurrence of restenosis, the development of new stenotic lesion, the change of glycemic status | — |
Countries
Japan
Outcome results
None listed