Patients with AMI who are candidates for PCI(first episode of AMI)
Conditions
Interventions
In the nicorandil group, after a bolus injection of nicorandil(0.067 mg/kg), it is continuously infused intravenously at 1.67ug/kg·
min for 24h.
In the control group, seline is continuously infused intravenously for 24h.
Sponsors
National Cardiovascular Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 20–79 years 2. Chest pain of more than 30 min 3. 0.1 mV ST-segment elevation in 2 contiguous ECG leads 4. Admission to hospital within 12 h of symptom onset 5. First episode of AMI 6. Candidates for PCI
Exclusion criteria
Exclusion criteria: 1. History of old myocardial infarction 2. Left main coronary artery stenosis 3. Severe liver and/or kidney dysfunction 4. Suspected aortic dissection 5. History of coronary artery bypass graft 6. History of allergic response to drugs 7. Severe hypovolemia 8. Right ventricular infarction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (1) estimated infarct size and (2) left ventricular function (left ventricular ejection fraction and end-diastolic volume) and regional wall motion. | — |
Secondary
| Measure | Time frame |
|---|---|
| (1) survival rate (2)cardiovascular events (ie, cardiac death, nonfatal re-infarction, re-hospitalization because of cardiac disease, revascularization) (3) reperfusion injury (ie, malignant ventricular arrhythmia during reperfusion periods, re-elevation of ST-segment, worsening of chest pain) (4) the association of SNPs of ANP-related genes with response to ANP treatment | — |
Countries
Japan
Outcome results
None listed