A randomized controlled trial to compare surgical effectiveness of tumor enucleation versus systematic segmentectomy for resecting hepatocellular carcinoma

A randomized controlled trial to compare surgical effectiveness of tumor enucleation versus systematic segmentectomy for resecting hepatocellular carcinoma - A randomized comparison of enucleation versus segmentectomy for hepatocellular carcinoma

Status

Unknown

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000086

Enrollment

120

Registered

2005-11-01

Start date

2003-04-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cases with hepatocellular carcinoma scheduled to undergo hepatic resection.

Interventions

As an operative procedure, the patients are randomly assigned to undergo tumor enucleation for resecting hepatocellular carcinoma. As an operative procedure, the patients are randomly assigned to unde

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Clinically-proven hepatocellular carcinoma less than 50 mm in diameter. 2. Stage-1, 2, or 3 tumor in UICC-TNM classification. 3. Hepatic function of no ascites, total serum bilirubin value less than 1.0mg/dL, and indocyanine clearance rate less than 30%.

Exclusion criteria

Exclusion criteria: 1. Recurrent hepatocellular carcinoma within 2 years after primary hepatic resection. 2. Multiple hepatocellular carcinoma. 3. Simultaneous other malignant disorders.

Design outcomes

Primary

Measure	Time frame
Disease-free survival	—

Secondary

Measure	Time frame
Overall survival, disease-specific survival, postoperative complication	—

Countries

Japan

Contacts

Public ContactTadatoshi Takayama

Nihon University School of Medicine Department of Digestive Surgery

takayama.tadatoshi@nihon-u.ac.jp03-3554-2345

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026