A Multicenter Randomized Controlled Trial Designed to Evaluate Follow-up Surveillance Strategies for Colorectal Cancer: The Japan Polyp Study

A Multicenter Randomized Controlled Trial Designed to Evaluate Follow-up Surveillance Strategies for Colorectal Cancer: The Japan Polyp Study - The Japan Polyp Study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000058

Enrollment

3000

Registered

2005-08-12

Start date

2003-02-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal Neoplasm

Interventions

1, 3 year follow-up after two complete colonoscopies with the removal of all polyps detected 3 year follow-up after two complete colonoscopies with the removal of all polyps detected

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who undergo colonoscopy.

Exclusion criteria

Exclusion criteria: Patients who have a family or personal history of familial polyposis, HNPCC, inflammatory bowel disease, or a personal history of polypectomy with unknown histology, who have not had invasive colorectal cancer or colectomy have been considered for exnclusion.

Design outcomes

Primary

Measure	Time frame
The primary goal is to address the hypothesis that after two complete colonoscopies with the removal of all polyps detected, the incidence of clinically significant lesions would not be different between patients undergoing two further follow-up examinations and those undergoing just one. Clinically significant lesions are defined as index lesions (IL): if they are larger than 10mm; if they have high-grade dysplasia; or if they are invasive.	—

Measure

Time frame

The primary goal is to address the hypothesis that after two complete colonoscopies with the removal of all polyps detected, the incidence of clinically significant lesions would not be different between patients undergoing two further follow-up examinations and those undergoing just one. Clinically significant lesions are defined as index lesions (IL): if they are larger than 10mm; if they have high-grade dysplasia; or if they are invasive.

—

Secondary

Measure	Time frame
Colorectal cancer morbidity and mortality	—

Countries

Japan

Contacts

Public ContactMika Mori

National Cancer Center Hospital (NCCH) Cancer Screening Center/ Endoscopy division

mmori@ncc.go.jp03-3542-2511

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026