stable angina pectoris with mild hypertension
Conditions
Interventions
1) Olmesartan
2) Valsartan
Sponsors
The Department of Cardiology, Nagoya University Graduate School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients with mild hypertension, who have been treated with statins more than 8 weeks before the randomization
Exclusion criteria
Exclusion criteria: (non-lesion related items) 1)Patients with acute coronary syndrome 2)Previous history of Q myocardial infarction within 4 weeks before the randomization 3)Low left ventricular(LV) function(LV ejection fraction 3.0mg) 5)Patients who are treated with angiotensin converting enzyme inhibitor or receptor blocker, or aldosterone receptor blocker at randomization (lesion related items) 1)chronic total coronary artery occlusion 2)lesions on bypass grafts 3)unsuccessful stent implantation (stenosis > 50% after PCI) 4)lesions with prior atheroablative procedures before stent implantation 5)lesions implanted with multiple stents 6)left main trunk lesions 7)lesions on small vessels(reference diameter < 2.0 mm) 8)calcified lesions, which preclude accurate quantification of IVUS imaging
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| nominal changes in % plaque volumes by three-dimensional intravascular ultrasound at 6-8 months follow-up after percutaneous coronary intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| (IMT) change from baseline in mean IMT after 6-8 months (E/A) change from baseline in E/A after 6-8 months by echocardiography (laboratory test) hs-CRP, adiponectine, aldosterone, renin, oxLDL, HOMA-R, TC, TG, LDL-C, HDL-C, etc | — |
Countries
Japan
Contacts
Public ContactHideki Ishii
Nagoya University Graduate School of Medicine The Department of Cardiology
Outcome results
None listed