A multicenter randomized controlled trial cyclosporine treatment for frequently relapsing nephrotic syndrome in childhood

A multicenter randomized controlled trial cyclosporine treatment for frequently relapsing nephrotic syndrome in childhood - A randomized controlled trial of cyclosporine treatment for frequently relapsing nephrotic syndrome in childhood

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000014

Enrollment

Registered

2005-08-01

Start date

1996-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frequently relapsing nephrotic syndrome in children

Interventions

Cyclosporine C0 monitoring with 80-100ng/mL for first 6 months and with 60-80ng/mL for the following 18 months. Cyclosporine C0 monitoring with 80-100ng/mL for first 6 months and Cyclosporine administ

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Primary nephrotic syndrome. 2.Frequently relapsing, based on the International study of kidney disease in children. 3.Biopsy diagnoses of MCNS, where a renal biopsy has been performed before eligibility. 4.Aged under 18 years. 5.Written informed consent from the patients' parents or legal guardians.

Exclusion criteria

Exclusion criteria: 1.Other renal or systemic forms of nephrotic syndrome defined on renal biopsy, clinical features or serology (Henoch-Schönlein nephritis, systemic lupus erythematosus). 2.History of cyclosporine administration.

Design outcomes

Primary

Measure	Time frame
relapse-free survival	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026