Cyclosporine C0 monitoring for frequently relapsing nephrotic syndrome in children

Cyclosporine C0 monitoring for frequently relapsing nephrotic syndrome in children - Cyclosporine C0 monitoring for frequently relapsing nephrotic syndrome in children

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000010

Enrollment

Registered

2005-08-01

Start date

2000-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Frequently relapsing nephrotic syndrome in children

Interventions

Cyclosporine C0 monitoring

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Primary nephrotic syndrome (proteinuria with a urinary protein-creatinine ratio >1.8 and hypoalbuminemia with serum albumin level <2.5 g/dL). 2.Frequently relapses or prednisolone dependence, based on the International study of kidney disease in children. 3.Biopsy diagnoses of MCNS, MPGN or FSGS, where a renal biopsy has been performed before eligibility. 4.Aged twelve months to 18 years. 5.Written informed consent from the patients' parents or legal guardians.

Exclusion criteria

Exclusion criteria: 1.Other renal or systemic forms of nephrotic syndrome defined on renal biopsy, clinical features or serology (Henoch-Schönlein nephritis, systemic lupus erythematosus). 2.History of steroid-resistance. 3.Medical history of allergy or hypersensitivity reactions to cyclosporine. 4.Poorly controlled hypertension. 5.Chronic renal dysfunction. 6.Active infectious disease. 7.Severe liver disfunction. 8.History of cyclosporine administration. 9.Pregnancy. 10.Judged inappropriate for this study by the physicians.

Design outcomes

Primary

Measure	Time frame
Relapse-free rate	—

Countries

Japan

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026