Frequently relapsing nephrotic syndrome in children
Conditions
Interventions
Cyclosporine C2 monitoring with higher target levels
Cyclosporine C2 monitoring by lower target levels
Sponsors
Japanese Study Group of Kidney Disease in Children
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Primary nephrotic syndrome (proteinuria with a urinary protein-creatinine ratio >1.8 and hypoalbuminemia with serum albumin level <2.5 g/dL). 2.Frequently relapse or steroid independence, based on the International study of kidney disease in children. 3.Biopsy diagnoses of MCNS, MPGN or FSGS, where a renal biopsy has been performed within 12 months before eligibility. 4.Aged twelve months to 18 years. 5.Written informed consent from the patients' parents or legal guardians.
Exclusion criteria
Exclusion criteria: 1.Other renal or systemic forms of nephrotic syndrome defined on renal biopsy, clinical features or serology (Henoch-Sch&ouml;nlein nephritis, systemic lupus erythematosus). 2.History of steroid resistance. 3.Medical history of allergy or hypersensitivity reactions to cyclosporine. 4.Poorly controlled hypertension. 5.Chronic renal dysfunction. 6.Active infectious disease. 7.Severe liver disfunction. 8.History of cyclosporine administration. 9.Pregnancy. 10.Judged inappropriate for this study by the physicians.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relapse-free rate | — |
Countries
Japan
Contacts
Public ContactNakanishi
Japanese Study Group of Kidney Disease in Children Department of Pediatrics, Wakayama Medical University
Outcome results
None listed