Lisinopril only and a combination of lisinopril and losartan for IgA nephropathy with focal mesangial proliferation in children: A randomized controlled trial of efficacy and safety

Lisinopril only and a combination of lisinopril and losartan for IgA nephropathy with focal mesangial proliferation in children: A randomized controlled trial of efficacy and safety - Lisinopril only and a combination of lisinopril and losartan: A randomized controlled trial(JSKDC01)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-C000000006

Enrollment

110

Registered

2005-08-01

Start date

2005-01-01

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

IgA nephropathy in children

Interventions

Lisinopril for 2 years Lisinopril+losartan for 2 years

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Biopsy diagnoses of IgA nephropathy with focal mesangial proliferation, where a renal biopsy has been performed within 4 months before eligibility. 2.Proteinuria with a urinary protein-creatinine ratio >0.2. 4.Aged 2 to 18 years. 5.Written informed consent from the patients' parents or legal guardians.

Exclusion criteria

Exclusion criteria: 1.Other renal or systemic forms of nephrotic syndrome defined on renal biopsy, clinical features or serology (Henoch-Schönlein nephritis, systemic lupus erythematosus). 2.Medical history of allergy or hypersensitivity reactions to lisinopuril and losartan. 3.Chronic renal dysfunction. 4.Active infectious disease. 5.Severe liver disfunction. 6.History of steroid, immunosupression, ACEI and ARB administration. 7.History of Saireito or dipilidamol administration. 8.Pregnancy. 9.Judged inappropriate for this study by the physicians.

Design outcomes

Primary

Measure	Time frame
Disappearance rate of proteinuria	—

Countries

Japan

Contacts

Public ContactNakanishi

Japanese Study Group of Kidney Disease in Children Department of Pediatrics, Wakayama Medical University

jskdc@wakayama-med.ac.jp073-441-0633

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026