Intra articular ozone injection combined with Compound Angelica sinensis + vitamin B12 under ultrasound in the treatment of knee osteoarthritis

Ultrasonic intra-articular injection of ozone combined with Compound Angelica and vitamin B12 in the treatment of knee osteoarthritis: a randomized, controlled, single blind clinical study

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ITMCTR

Registry ID

ITMCTR2200006860

Enrollment

Unknown

Registered

2022-12-13

Start date

2022-12-15

Completion date

Unknown

Last updated

2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

control group:Ozone + sodium hyaluronate

Study group:Ozone + Compound Angelica Injection

Eligibility

Sex/Gender

All

Age

38 Years to 90 Years

Inclusion criteria

Inclusion criteria: Patients who meet the clinical diagnostic criteria for knee osteoarthritis recommended by the American College of rheumatology: (1) Knee pain on most days in the past month; (2) Bouncing sound during joint movement; (3) Knee stiffness 38; (5) Knee joint bone fat with bouncing sound; (6) Bone fat without bouncing. Knee osteoarthritis can be diagnosed when the patient has (1) pain, accompanied by (2), (3), (4), (2), (3), (5) or (6).

Exclusion criteria

Exclusion criteria: (1) Unable to cooperate with the assessment; (2) Allergic to the drugs used; (3) Emergency treatment is needed in case of emergency; (4) Age = 38 years; (5) Severe cardiopulmonary insufficiency; (6) Severe hepatic and renal insufficiency.

Design outcomes

Primary

Measure	Time frame
VAS;	—

Secondary

Measure	Time frame
Walking distance, Insall knee joint efficacy;	—

Countries

China

Contacts

Public ContactXuehai Guan

guan_xh@aliyun.com+8618587697310

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026