Generalized anxiety disorder
Conditions
Interventions
Treatment group1:Acupuncture plus conventional western medicine
Treatment group2:Acupuncture plus conventional western medicine
Control group1:Sham acupuncture plus conventional western medicine
Control group 3 ( healthy people ):non-interposition
Control group2:Sham acupuncture plus conventional western medicine
Sponsors
Shenzhen Bao'an Traditional Chinese Medicine Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria of GAD patients under epidemic situation: ( 1 ) Patients who met the above diagnostic criteria of generalized anxiety disorder in Chinese and Western medicine and were diagnosed in the context of the new coronavirus epidemic ; ( 2 ) Hamilton Anxiety Scale ( HAMA ) 14 determination = 14 points and < 29 points ; ( 3 ) Age = 18 years, = 65 years ; ( 4 ) those who have not received medication, physical or psychological treatment in the past three weeks, or those in stable condition ; signed informed consent and volunteered to participate in this study. Inclusion criteria for healthy people: (1) Age = 18, = 65; (2) Right handed, regardless of gender; (3) He has been in good health without any discomfort in the past month; (4) No central stimulation (rTMS, TDCS, etc.) or peripheral stimulation (acupuncture, transcutaneous electrical stimulation, etc.) in recent 3 months; (5) No history of illegal drug use and excessive drinking; (6) Those who signed the informed consent form and volunteered to participate in the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria for GAD patients under epidemic situation: ( 1 ) Patients who do not meet the inclusion criteria ; ( 2 ) patients with a history of brain trauma, epilepsy, or accompanied by liver and kidney dysfunction, metal implants or severe physical organic diseases such as cardiovascular, cerebrovascular, liver and kidney ; ( 3 ) Patients with other anxiety symptoms of schizophrenia, bipolar disorder or other mental disorders, physical illness ; ( 4 ) Patients with previous or current suicide plan or behavior, psychotic symptoms or anxiety caused by alcohol, drug abuse or withdrawal after addiction ; ( 5 ) Patients with poor compliance or fear of acupuncture ; ( 6 ) Left-handed ; ( 7 ) Pregnant and lactating women. Exclusion criteria for healthy population: (1) People with speech disorder; (2) Hypertension, diabetes and major heart, liver, kidney and other organ diseases; (3) Have a history of dementia, psychosis, epilepsy and other neurological diseases; (4) History of craniocerebral trauma and operation; (5) There are metal residues in the body (including dentures, pacemakers, nerve stimulators, medical pumps, etc.); (6) Those who are afraid of TMS and are unable to perform TMS stimulation for other reasons; (7) Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Transcranial magnetic stimulation detection ( rMT, MEP, CSP and PAS10, PAS25 );Related Scale Assessment ( Hamilton Anxiety Scale, State-Trait Anxiety Questionnaire ); | — |
Secondary
| Measure | Time frame |
|---|---|
| Peripheral blood tests, including: 5-hydroxytryptamine (5-HT), glutamic acid (Glu), glutamamide (Gln), gamma-aminobutyric acid (GABA), brain-derived neurotrophic factor (BDNF); | — |
Countries
China
Contacts
Public Contactzhou xiayun
Outcome results
None listed