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The effect of cortical motor center phrenic nerve circuit regulated by nerve on pulmonary rehabilitation of COPD

The effect of cortical motor center phrenic nerve circuit regulated by nerve on pulmonary rehabilitation of COPD

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200006800
Enrollment
Unknown
Registered
2022-11-21
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COPD

Interventions

Test group:Magnetic stimulation of bilateral cortical motor area+phrenic nerve
control group:Basic treatment (use at least one bronchodilator)

Sponsors

Shaanxi Traditional Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: ? Aged 18-80 (including 18 and 80); ? Patients with severe chronic obstructive pulmonary disease (COPD) in group C meeting the diagnostic criteria; ? There is no acute exacerbation within 4 weeks (the patient is in the stable period, or the inpatients in the acute exacerbation period enter the stable period after standardized treatment); ? Sign the informed consent;

Exclusion criteria

Exclusion criteria: ? COPD patients with asthma, pulmonary tuberculosis, bronchiectasis, lung cancer and other patients who are not suitable for pulmonary rehabilitation; ? COPD patients with serious cardiovascular, cerebrovascular, liver, kidney, blood, endocrine and other major diseases; ? Patients with severe musculoskeletal diseases; ? There are metal foreign bodies within 30cm of the treatment site; ? Long term oxygen inhalation is required. Spontaneous pneumothorax or recurrent pneumothorax, giant pulmonary bullae and rib fracture have occurred in the past six months; ? High spinal cord injury, muscle disease; ? No drugs that affect nerve conduction and muscle contraction, such as vecuronium bromide, benzodiazepines and aminoglycosides, were used within one week.

Design outcomes

Primary

MeasureTime frame
Pulmonary function;Phrenic motor evoked potential;Blood gas analysis;

Secondary

MeasureTime frame
6-minute walk distance measurement;MCSS score;CAT score;MMRC score;

Countries

China

Contacts

Public ContactGaohuan
gaohuan0625@163.com15991902186

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026