Urticaria itching
Conditions
Interventions
Active Acupuncture group:Park sham device+Active Acupuncture
Sham Acupuncture group:Park sham device+Sham Acupuncture
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Those who meet the diagnostic criteria for "CSU/chronic addiction rash" in "EAACI/GA2LEN/EDF/WAO Guidelines for Definition, Classification, Diagnosis and Treatment of Urticaria" and "Traditional Chinese Medicine Diagnosis and Efficacy Criteria for Diseases and Syndrome"; (2) Right-handed; 18 years old = age = 70 years old, education = 6 years, both male and female; (3) 7-day urticaria activity score (Urticaria Activity Score 7, UAS7)>14; (4) There are no metal implants in the body, and there is no contraindication to fMRI scanning; (5) No antihistamines within 2 weeks before entering the study, no steroid hormones and immunosuppressive drugs within 1 month; (6) Those who did not receive acupuncture and moxibustion treatment or participated in other ongoing clinical investigators 3 months before entering the study; (7) Sign the informed consent form and voluntarily participate in this researcher. Note: Only patients who meet the above 7 items can be included in this study.
Exclusion criteria
Exclusion criteria: (1) Those with claustrophobia and other contraindications to MRI; (2) Journalists who cannot understand or record the urticaria day; (3) Pregnant women and lactating women; (4) Patients with serious primary diseases such as cardiovascular, liver, kidney, digestive and hematopoietic systems; (5) Progressive malignant tumor or other serious wasting diseases, who are prone to infection and bleeding; (6) Those who are unconscious, unable to express subjective discomfort symptoms or mentally ill; (7) Participated in similar researchers within 1 month. Note: All patients who meet any one of the above items will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urticaria Activity Score 7,UAS7; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dermatology Life Quality Index,DLQI;Pruritus Visual Analogue Scale,VAS-P;Hamilton Depression Scale,HAMD;skin flora;Pittsburgh Sleep Quality Index,PSQI;skin reactions (diameter, height, temperature, humidity, etc.);Intestinal flora;Brain functional MRI (resting state, dynamic functional connectivity; analysis of microstate extraction techniques);Blood sample index (blood routine, liver and kidney function, total IgE, cytokines, etc.);Hamilton Anxiety Scale,HAMA;Demographics, vital signs and condition data; | — |
Countries
China
Contacts
Public ContactZhang Leixiao
Outcome results
None listed