Mild to moderate depressive disorder
Conditions
Interventions
Yang deficiency constitution without disease group:Lifestyle intervention
Mild constitution group:Lifestyle intervention
Sponsors
Beijing University of traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: (1) Han nationality, aged from 18 to 60 years old, male or female; (2) Those with simple constitution or combined constitution that meet the criteria of mild constitution / yang deficiency constitution; (3) 17 items Hamilton Depression Scale (HAMD-17) score < 7; (4) Among those with Yang deficiency constitution, those with kidney yang deficiency; (5) Normal routine physical examination or no other clear disease diagnosis; (6) Living in Beijing in recent 2 years; (7) Know and understand the contents of this study, and voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Those with more than two other constitutions; (2) Special dual Constitution: mild constitution and yang deficiency constitution tendency, qi depression constitution tendency, Yang deficiency constitution and qi depression constitution; (3) Those who have used glucocorticoids, antibiotics, microecological regulators and gastrointestinal motility drugs in the past month; (4) Those who participated in clinical research of other drugs within 1 month before screening.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral plasma neurotransmitter concentration;Feces 16S;Score of TCM constitution Scale;FS-14;Serum non targeted metabolome;SHAPs;Fecal metagenome;HAMD17;Fecal metabolome;Rapid assessment scale of depression QIDS-SR16; | — |
Countries
China
Contacts
Public ContactYingshuai Li
Beijing University of traditional Chinese Medicine
Outcome results
None listed