Idiopathic membranous nephropathy
Conditions
Interventions
Chinese medicine treatment group:Traditional Chinese medicine
Western medicine control group:CsA
Sponsors
Xiyuan Hospital, China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: (1) Kidney biopsy pathological diagnosis of MN, or positive anti-PLA2R antibody; (2) Meet the diagnostic criteria of spleen deficiency syndrome; (3) The course of disease is longer than 6 months; (4) Urine protein was quantified at 3-8g /24h; (5) Blood pressure can be effectively controlled at =140/90mmHg; (6) eGFR 45 ml/min or more, (7) 18-70 years old, no gender limitation; (8) Antibiotics and probiotics have not been used in the past one month; (9) Body mass index (BMI) between 18.5 and 28.5 kg/m2; (10) Signed informed consent.
Exclusion criteria
Exclusion criteria: (1) Exclude secondary membranous nephropathy (including tumor-related membranous nephropathy, hepatitis B-related membranous nephropathy, lupus membranous nephropathy, drug and toxin-related membranous nephropathy); (2) the eGFR < 45 ml/min. (3) hormone and/or immunosuppressant treatment within 6 months; (4) women who have pregnancy plan, pregnancy or breast-feeding period; (5) complicated with serious diseases of heart, brain, liver and hematopoietic system, or other serious diseases affecting their survival; (6) Metabolic diseases such as obesity and diabetes; (7) History of gastrointestinal diseases or gastrointestinal surgery (except appendectomy); (8) Rheumatoid arthritis, sjogren's syndrome and other autoimmune diseases; (9) Antibiotics and probiotics were used within the past one month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intestinal flora;AHR;Intestinal microbiota metabolites; | — |
Secondary
| Measure | Time frame |
|---|---|
| Interleukin;Urine protein quantification at 24 hours;Th17;biochemical;PLA2R;Treg; | — |
Countries
China
Contacts
Public ContactLang Rui
Outcome results
None listed