Tic Disorder
Conditions
Interventions
Control Group:none
TD group-Genetic group:JingxinZhidongfang
TD group-Non Genetic group:Jingxin Zhidongfang
Sponsors
Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
5 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1. TD group inclusion criteria: (1) TD patients of all ages treated in the Department of Pediatrics of Guang 'anmen Hospital from May 2022 to October 2023; (2) There were 20 TD patients with genetic history (TD in relatives within three generations) and 20 TD patients without genetic history; (3) Patients who had not been treated before the first visit; (4) No specific changes were found in electroencephalogram examination, and the return of liver and kidney function tests was normal; (5) Obtain the consent of the child's parents and sign the informed consent form. 2.Non-TD group inclusion criteria: (1) Children undergoing physical examination in Guang'anmen Hospital, Chinese Academy of Chinese Medical Sciences; (2) The age of patients in TD group should be as consistent as possible; (3) Patients with no previous history of chorea, athetosis, autism, Wilson disease, childhood schizophrenia, epilepsy, drug-induced, tardy-onset dyskinesia, hysteria or acute motor disorders; (4) Obtain consent from parents of children and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. TD group exclusion criteria: (1) Patients with history of Wilson disease, rheumatic chorea, childhood migraine, epilepsy, mental retardation and schizophrenia were excluded; (2) Patients with inherited metabolic history; Those with serious physical diseases; Patients with arrhythmia and abnormal liver and kidney function; Have a history of drug allergy; (3) The patient's parents were genetically identified as non-biological parents; (4) Patients who refuse to sign written informed consent. 2. Non-TD group exclusion criteria: (1) Refuse to sign the informed consent form; (2) Abnormal maternal pregnancy and birth history; (3) Patients with obvious abnormal returns from physical examination of liver and kidney function and routine urine tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| DNA methylation;Yale comprehensive tic severity scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Side effect scale; | — |
Countries
China
Contacts
Public ContactFei Han
Outcome results
None listed