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Investigating the clinical efficacy and mechanism of Runfei Huayu recipe in treating connective tissue disease merger interstitial lung disease based on Th17/Treg glycolytic pathway

Investigating the clinical efficacy and mechanism of Runfei Huayu recipe in treating connective tissue disease merger interstitial lung disease based on Th17/Treg glycolytic pathway

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Observational
Source
ITMCTR
Registry ID
ITMCTR2200006523
Enrollment
Unknown
Registered
2022-08-22
Start date
2022-08-22
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Connective tissue disease merger interstitial lung disease

Interventions

Control Group:Cyclophosphamide
Healthy control group:/
Experimental group:Runfei Huayu recipe
Experimental group:Prednisone
Experimental group:Cyclophosphamide

Sponsors

Taizhou Hospital of traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
35 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Meet the diagnostic criteria of traditional Chinese and western medicine for CTD-ILD; 2. 35 years = age =75 years, male or female; 3. This study was approved by the ethics committee of our hospital, and informed consent was obtained from patients with signed informed consent; 4. No fertility requirement.

Exclusion criteria

Exclusion criteria: 1. Patients with pulmonary tuberculosis, chronic obstructive pulmonary disease, emphysema, bronchiectasis, lung tumors, silicosis, pneumoconiosis and other lung diseases; 2. Patients with some serious primary diseases, such as digestive, respiratory, cardiovascular, hematopoietic and nervous system diseases, mental diseases, etc.; 3. Abnormal liver and kidney function, such as alanine aminotransferase (ALT) and aspartate aminotransferase (AST) exceeding 1.5 times the normal value, blood creatinine (Scr) and urea nitrogen (BUN) any higher than the normal value; 4. Allergic constitution and allergic to clinical study medication; 5. Women who are during pregnancy, preparing for pregnancy, or during breastfeeding period.

Design outcomes

Primary

MeasureTime frame
Lung function;Lung CT;

Secondary

MeasureTime frame
TCM syndrome integral;

Countries

China

Contacts

Public ContactLing Li
babyli@163.com13961011361

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026