bipolar disorder
Conditions
Interventions
Control group:Sodium valproate combined with bupropion
Study group:Sodium valproate combined with Acupuncture
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: We confirm the depressive episodes of bipolar disorder according to International Classifcation of Diseases 10th Edition (ICD-10). The participants meet the diagnostic criteria; no gender limitation, aged between 18 and 60; Hamilton-17 depression Scale score =18; no taken psychotropic drugs, or be cleaned for one week according to the provisions; voluntary participation, and informed consent signed by themselves and/or their guardians.
Exclusion criteria
Exclusion criteria: We exclude the patients according to any of the following 9 criteria in this clinical study: mental disorders caused by organic brain diseases; morbid psychoactive substance related disorder, cyclic mood disorder, rapid cycle bipolar disorder and personality disorder (ICD-10 diagnostic criteria); have aggressive behavior, or high suicidal risk; with serious physical diseases; have experienced obvious discomfort such as needle-sickness during acupuncture treatment; allergic to valproate, or stop taking valproate due to adverse reactions; pregnant or lactating women; have participated in other pharmaceutical clinical trials in the past one month; receive modified electroconvulsive treatment (MECT) in the last month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton-17 Depression Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| 8-week remission rate;Young's Manic Rating Scale;Hamilton Anxiety Scale;Clinical Global Impression Scale;2-week early onset rate;8-week response rate;Switching rate;Side effect Scale; | — |
Countries
China
Contacts
Public ContactYang Yang
Outcome results
None listed