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Observation of clinical efficacy and mechanism of brain plasticity in the treatment of generalized anxiety disorder by soothing the liver and adjusting the spirit acupuncture

Study on the clinical effect of regulating the liver and regulating the divine needle to intervene the anxiety state of quarantined persons related to epidemic and the related mechanism&#3

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200006447
Enrollment
Unknown
Registered
2022-08-08
Start date
2022-08-08
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Generalized anxiety disorder

Interventions

Treatment group :Acupuncture plus conventional western medicine

Sponsors

Shenzhen Bao'an Traditional Chinese Medicine Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: ? Meet the above diagnostic criteria of generalized anxiety disorder; ? Scores >14 and < 29 on 14 items of HAMAD; ? Age =18 years, =65 years; ? The course of disease =6 months, =2 years, the patients who have not received drug, physical or psychological treatment in the last 3 weeks, or whose condition is stable, the original drug treatment regimen has been maintained for at least 3 weeks; ? Signed informed consent and volunteered to participate in this study.

Exclusion criteria

Exclusion criteria: ? Patients with anxiety or depression before isolation, and patients with past or current suicidal plans or behavioral or psychotic symptoms of nSSI; ? Previous diagnosis of schizophrenia, bipolar disorder or other mental disorders; ? Have obvious history of personality disorder; (4) have a history of alcoholism or substance abuse; ? Previous history of brain trauma and epilepsy; ? Patients with liver and kidney dysfunction, metal implants or major diseases of cardiovascular and cerebrovascular systems whose condition cannot be controlled; ? Poor compliance or fear of acupuncture; ? left-handed; ? Pregnant and lactating women.

Design outcomes

Primary

MeasureTime frame
Evaluation of related scales (Hamilton Anxiety Scale, State Anxiety-trait Anxiety Questionnaire, Life Events Scale, post traumatic stress Disorder Self-rating Scale) ;Biochemical parameters (5-hydroxytryptamine, glutamic acid, glutamine amide, ? -aminobutyric acid, nerve growth factor);Cortical plasticity changes (PAS25, PAS10) ;

Countries

China

Contacts

Public ContactZhou peng
zpmm1999@163.com13714077462

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026