Knee osteoarthritis
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: Patients were included in our study aged 50-70 years, had been diagnosed with KOA according to the American College of Rheumatology criteria, had documented radiological alterations in the knee joint of grade 1 to 3 according to Kellgren-Lawrence criteria, and written informed consent.
Exclusion criteria
Exclusion criteria: pain caused by inflammatory, malignant, or autoimmune disease;or other reasons for pain, such as serious varus or valgus deformity of the knee; or had knee surgery,arthroscopy of the affected knee in the past year;chondroprotective or intra-articular injection in the past 4 months,or physiotherapy or corticoid treatments for pain (exception of NSAIDs) during the previous 4 weeks.Additional exclusion criteria were serious acute or chronic organic disease or mental disorder, pregnancy or breastfeeding, and blood coagulation disorders. Most participants ware recruited in outpatient clinics, a few patients spontaneously contacted trial centre.All participants provided written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WOMAC;synovial thickness and effusion depth;VSA;taken of druges; | — |
Countries
China