functional constipation with rectal hyposensitivity
Conditions
Interventions
Polyethylene glycol 4000:Polyethylene glycol 4000
Yiqi Kaimi Recipe:Yiqi Kaimi Recipe
Yiqi Kaimi Recipe + biofeedback:Yiqi Kaimi Recipe combined with biofeedback
Sponsors
Longhua Hospital Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Diagnostic with functional constipation by Rome ?;and Diagnostic with low rectal sensitivity:Rectal sensation measurement: the minimum sensation threshold is more than 20ml, the initial defecation threshold is more than 60ml or the maximum tolerance threshold is more than 250ml, which meet one or more requirements. (2) syndrome with Qi and yin deficiency in traditional Chinese medicine; (3) Unlimited course of disease; (4) Patients aged from 18 to 80 (regardless of gender); (5) Patients who have signed informed consent. v
Exclusion criteria
Exclusion criteria: (1) Excluding those who do not meet the diagnostic criteria and inclusion criteria. (2) There are malignant intestinal lesions, or perianal acute infection and bleeding diseases. (3) There are serious diseases such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system, and psychiatric patients. (4) diabetic patients with impaired glucose control (fasting blood glucose > 7.8mmol/L). (5) Patients with severe infection and critical condition. (6) Pregnant or lactating women, allergic constitution or abnormal liver function. (7) According to the judgment of the researcher, other medical histories that reduce the possibility of enrollment or complicate enrollment, such as frequent changes in the working environment, are easy to cause loss of follow-up. (8) Subjects participating in clinical studies of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cleveland clinic score, CCS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Patient assessment of constipation quality of life;Patient assessment of constipation symptom, PAC-SYM; Gastrointestinal electromyography;Rectal sensation;Anorectal manometry; | — |
Countries
China
Contacts
Public ContactWang Chen
Outcome results
None listed