subjective cognitive decline
Conditions
Interventions
Sponsors
First Affiliated Hospital, Guangxi University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with MCI diagnostic criteria consistent;2.55 to 70 years old, right-handed3The main complaint is about the decline of memory;4Chinese native speaker, education level of more than 6 years, MMSE: junior high school and above > 27 points5the ability of daily life unaffected or slight affected6No visual, auditory or intellectual impairment, no language barrier, can answer and fill in the questionnaire smoothly;7.Without acupuncture and moxibustion treatment for nearly 1 month,No psychotropic drugs affecting cognition were taken before and during treatment8All subjects obtained informed consent, voluntarily cooperated and signed informed consent.
Exclusion criteria
Exclusion criteria: (1) MCI, AD prodrome, dementia;(2) Other neurological diseases that can lead to cognitive decline, except for suspected early AD, such as Parkinson's disease, vascular-derived dementia, and brain tumors;(3) Patients with severe systemic diseases such as heart, liver and renal insufficiency and other systemic diseases that can cause cognitive decline, such as thyroid dysfunction, anemia, hepatic encephalopathy, renal encephalopathy, etc.;(4) Abnormal brain structure, such as intellectual development disorder, brain infection, cerebral infarction, cerebral hemorrhage and a history of severe head trauma or other diseases involving the central nervous system, thus affecting the neuropsychological scale assessment;(5) A history of depression, anxiety, bidirectional disorder, schizophrenia and other mental disorders;(6) History of substance or substance abuse / addiction in the past 1 year;(7) Those who have received cognitive function-related treatment in the past 1 month;(8) Severe hearing, visual impairment and aphasia who are unable to evaluate or complete the test;, (9) those with metal residues in the body and unable to perform MRI examination;(10) Failure to complete the project due to any other uncertain situation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diffusion Tensor Imaging;Magnetic Resonance Spectroscopy;resting-state fMRI;Apparent Diffusion Coefficient;scales;Serum oestradiol, testosterone, and progesterone levels; | — |
Countries
China
Contacts
Public ContactLihua zhao
Outcome results
None listed