Metabolically associated fatty liver disease
Conditions
Interventions
trial group:Chinese medicine ( Linghe granules ) granules
control group:Chinese medicine placebo granules
Sponsors
Xiamen Hospital of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Referring to diagnostic criteria for MAFLD based on the new definition of metabolic fatty liver disease in 2020, the diagnostic criteria of Phlegm, Dampness and Blood Stasis Syndrome established by the consensus opinion on the diagnosis and treatment of non-alcoholic fatty liver disease by integrated traditional Chinese and western medicine (2017) are as follows::?Age 18-60 years; ?Compliance with MAFLD (obesity type) diagnostic criteria and TCM phlegm, dampness, blood stasis syndrome diagnostic criteria; ?24=BMI 8 %, willing to accept regular physical and chemical examinations; ?Sign informed consent.
Exclusion criteria
Exclusion criteria: ?Alanine aminotransferase / aspartate aminotransferase > 5 × ULN ( standard upper limit ), total bilirubin > 2 × ULN; ?Alcoholic fatty liver disease; ?Combined with viral, autoimmune and other liver diseases, or taking drugs that may cause fatty liver; ?Combined with diabetes, malignant tumors, connective tissue diseases and severe heart, liver, hematopoietic, and nervous system complications , Or clearly have other important diseases; ?TCM Syndrome Differentiation of Liver and Kidney Yin Deficiency, Spleen and Kidney Yang Deficiency and Other Typical Deficiency Syndrome; ?Pregnant or breastfeeding women, allergic physique, allergic to drugs, and patients with mental illness; ?Patients who have undergone gastrointestinal bariatric surgery within the past year or who have taken weight-loss drugs within the past three months have lost >10%; ?Patients who took other therapeutic drugs in the past three months affected efficacy evaluation or participated in other clinical trials in the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI PDFF; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fibro Touch (CAP);weight;waist;blood fat;liver function;Uric Acid;blood glucose test;Self-made PRO Symptoms and Signs Scale; | — |
Countries
China
Contacts
Public ContactCaihong
Xiamen Hospital of TCM
Outcome results
None listed