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Study on the brain network mechanism of transcutaneous auricular vagus nerve stimulation in the treatment of ulcerative colitis based on functional magnetic resonance imaging

Study on the brain network mechanism of transcutaneous auricular vagus nerve stimulation in the treatment of ulcerative colitis based on functional magnetic resonance imaging

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005997
Enrollment
Unknown
Registered
2022-05-12
Start date
2022-06-01
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative colitis

Interventions

Sponsors

Wangjing Hospital, Chinese Academy of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Patients who meet the following six items must also be included in this study: (1) There are colonoscopy and pathological diagnosis reports of tertiary hospitals that meet the diagnostic criteria for ulcerative colitis; (2) The lesions range from rectum (E1) or left colon (E2) or total colon type (E3); (3) Mayo defecation score or bloody stool score of 1 or 2 points, and the disease activity is mild and moderate; (4) Those between the ages of 18 and 70; (5) Subjects should only take mesalazine before entering the group; (6) Voluntary examination and I will sign the informed consent form. Criteria for the diagnosis of Ulcerative Colitis: According to ACG Clinical Guideline: Ulcerative Colitis in Adults, the diagnosis should be made based on the exclusion of infectious and non-infectious Colitis by comprehensive analysis of Clinical manifestations, endoscopy, and histopathology.

Exclusion criteria

Exclusion criteria: Patients who meet one or more of the following items shall be excluded: (1) Those with serious complications, such as local stenosis, intestinal obstruction, intestinal perforation, toxic megacolon, rectal cancer, colon cancer and anal diseases; (2) Women who are pregnant or preparing for pregnancy and lactating women; (3) Patients with severe primary diseases such as liver, kidney, hematopoietic system and endocrine system and psychosis; (4) Suspected or do have a history of alcohol, drug abuse and mental patients; (5) According to the judgment of the researcher, it is not suitable to participate in this researcher; (6) Patients involved in other body surface electrical stimulation or acupuncture therapy in the original treatment plan; (7) Patients with skin lesions such as ulcer in the ear. (8) Known patients with amino salicylic acid allergies. (9) Patients who have been diagnosed with anxiety or depression before the diagnosis of ulcer colitis.

Design outcomes

Primary

MeasureTime frame
Concentration of fecal calcium sanitrin;Mayo defecation count rating;Mayo bloody stool score;heart rate variability;Brain function magnetic resonance data acquisition;Serum inflammatory cytokines;

Countries

China

Contacts

Public ContactYiqing Zhang
xhww1979@163.com13699183372

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026