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Based on gut microbiota-gut-brain axis to explore the clinical of electroacupuncture in the treatment of post-stroke cognitive impairment

Based on gut microbiota-gut-brain axis to explore the clinical of electroacupuncture in the treatment of post-stroke cognitive impairment

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
ITMCTR
Registry ID
ITMCTR2200005975
Enrollment
Unknown
Registered
2022-05-05
Start date
2022-05-22
Completion date
Unknown
Last updated
2023-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

control group:Basic treatment
Tongdu Xingshen acupuncture group:On the basis of basic treatment, Tongdu Xingshen acupuncture was given

Sponsors

The First Affiliated Hospital of Henan University of Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
30 Years to 75 Years

Inclusion criteria

Inclusion criteria: ?China guidelines for the diagnosis and treatment of acute ischemic stroke 2018 and China guidelines for the prevention and treatment of cerebrovascular diseases;?were confirmed to have a history of ischemic stroke by CT or MRI;?were determined the degree of cognitive impairment after assessing by mini-mental state examination (MMSE) and Montreal Cognitive Assessment (MoCA) which occurred after ischemic stroke;?are already ill more than or equal to one month and less than or equal to one year; ?never use drugs improving cognitive function were used before enrollment;?are conscious and have stable vital signs.

Exclusion criteria

Exclusion criteria: ?Participants suffered from other diseases that could lead to cognitive impairment, such as intracranial space occupying lesions, brain trauma, aneurysms, etc;?Patients with other diseases will lead to the failure of cognitive impairment examination, such as abnormal audio-visual function, mental disorder and so on;?The patient had cognitive impairment or had been diagnosed with dementia before this onset;?The patient has other serious diseases, such as immune diseases, endocrine diseases and abnormal liver and kidney function;?Women is pregnant or breastfeeding;?The patient has coagulation dysfunction.

Design outcomes

Primary

MeasureTime frame
ADL score (Barthel Index);Intestinal flora analysis;Detection of related indexes and factors of blood-brain barrier permeability;MMSE score;Inflammatory cytokines;MOCA score;

Countries

China

Contacts

Public ContactXiaodong Feng
fxd0502@163.com15303828605

Outcome results

None listed

Source: ITMCTR (via WHO ICTRP) · Data processed: Feb 4, 2026