Targeted Drug-Associated Diarrhea
Conditions
Interventions
test group:Oral Zisheng Antidiarrheal Recipe
Chinese medicine control group:Oral Shenling Baizhu Powder
Western medicine control group:Oral montmorillonite powder
Sponsors
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Those diagnosed with non-small cell lung cancer by histopathology; (2) Currently receiving targeted drug therapy and meeting the diagnostic criteria for mild or moderate diarrhea; (3) In line with the results of TCM syndrome differentiation of spleen and stomach weakness (4) Karnofsky score = 70 points, ZPS score = 2 points; (5) The age is 18-80 years old (inclusive), and the gender is not limited; (6) Estimated survival time > 3 months; (7) No intellectual or mental disorder, normal language expression ability, ability to judge their own general condition, and cooperative evaluation of diarrhea and quality of life; (8) Those who understand and agree to participate in this study and sign the informed consent form. Another 10 patients with non-targeted therapy for non-small cell lung cancer recruited were required to have no targeted therapy and were more than 2 weeks away from the oncology western medicine system treatment, such as chemotherapy, targeted therapy, radiotherapy, and immunotherapy.
Exclusion criteria
Exclusion criteria: 1. Those who do not meet the inclusion criteria; 2. Those with functional impairment of important organs; 3. Caused by other causes (such as irritable bowel syndrome, allergic enteritis, infectious diarrhea, infectious diarrhea, ulcerative colitis, malabsorption, parasitic infection, poisoning, bacillary dysentery, cholera, typhoid and paratyphoid fever) , diarrhea caused by radiation enteritis, hyperthyroidism, hypothyroidism, food and drug allergies, radiation enteritis, metabolic diseases, etc.); patients with persistent or chronic diarrhea before using targeted drugs; 4. Allergic constitution, allergic to montmorillonite powder and traditional Chinese medicine; 5. Those who cannot take the drugs involved in this clinical study; 6. Those who have participated in clinical trials of other drugs within the past 3 months; 7. Drugs that may affect gastrointestinal function and thus affect the judgment of efficacy have been used within one week (such as H-receptor antagonists, proton pump inhibitors, macrolide antibiotics, misoprostol, acarbose, lactose Fructose oral solution, biguanides, etc.); 8. Those with other progressive serious diseases (such as diabetes, hypertension, hyperthyroidism with serious complications); 9. Patients with serious complications (such as hypovolemic shock, gastrointestinal perforation, severe bleeding, nephrotic syndrome, etc.); 10. Women who are pregnant or breastfeeding, or women who have the desire to become pregnant in the near future; 11. Those with severe mental disorders or communication disorders; 12. Those who cannot follow up on schedule or those with poor compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| D-lactate;diamine oxidase;Gut flora;endotoxin; | — |
Countries
China
Contacts
Public ContactShiJun
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine
Outcome results
None listed